Silver
CASRN 7440-22-4 | DTXSID4024305
- IRIS Summary (PDF) (14 pp, 120 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(14 pp, 120 K)
Last Updated: 12/01/1991
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Dermal | 5 x 10 -3 | Argyria |
LOAEL
:
1.4
x 10-2 mg/kg-day |
3 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(14 pp, 120 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 120 K)
Last Updated: 06/01/1989
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- In animals, local sarcomas have been induced after implantation of foils and discs of silver. However, the interpretation of these findings has been questioned due to the phenomenon of solid-state carcinogenesis in which even insoluble solids such as plastic have been shown to result in local fibrosarcomas.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 120 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 120 K)
Not assessed under the IRIS Program.
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