Pentachlorophenol CASRN 87-86-5 | IRIS

IRIS

Pentachlorophenol

CASRN 87-86-5 | DTXSID7021106

Toxicological Review (PDF) (288 pp, 2.23 M)
IRIS Summary (PDF) (27 pp, 261 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (27 pp, 261 K) Last Updated: 09/30/2010

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	5 x 10 ^-3	Hepatotoxicity	LOAEL : 1.5 mg/kg-day	300	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (27 pp, 261 K) Last Updated: 09/30/2010
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (27 pp, 261 K) Last Updated: 09/30/2010

WOE Characterization	Framework for WOE Characterization
Likely to be carcinogenic to humans	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), PCP is "likely to be carcinogenic to humans."
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 261 K)

Oral Slope Factor: 4 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 1.1 x 10^-5 per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the POD (LED10).
Tumor site(s): Hepatic, Endocrine
Tumor type(s): Hepatocellular adenomas or carcinomas and adrenal benign or malignant pheochromocytomas (NTP, 1989)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 261 K)

Not Assessed under the IRIS Program.

Sep 2010: IRIS Toxicological Review of Pentachlorophenol (Final Report) (Report)

Jul 2010: IRIS Toxicological Review of Pentachlorophenol (Interagency Science Discussion Draft) (Report)

May 2009: IRIS Toxicological Review of Pentachlorophenol (External Review Draft) (Report)

May 2002: PENTACHLOROPHENOL: HEALTH AND ENVIRONMENTAL EFFECTS PROFILE (Report)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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