Perfluorohexanoic Acid (PFHxA)
CASRN 307-24-4 | DTXSID3031862
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(70 pp, 480 K)
Last Updated: 04/10/2023
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Developmental | 5 x 10 -4
(Chronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8
x 10-2 mg/kg-day |
100 | Medium |
| Developmental | 5 x 10 -4
(Subchronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8
x 10-2 mg/kg-day |
100 | Medium |
Note: BMDL 5%RD.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(70 pp, 480 K)
Last Updated: 04/10/2023
Information reviewed but value not estimated.
Note: NA
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(70 pp, 480 K)
Last Updated: 04/10/2023
Information reviewed but value not estimated.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (70 pp, 480 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (70 pp, 480 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Developmental |
5
x 10-4
(Chronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8 x 10-2 mg/kg-day |
100 | Medium | |
| Hepatic |
4
x 10-4
(Chronic) |
Increased hepatocellular hypertrophy in adult male Crl:CD Sprague‑Dawley rats |
BMD
(HED):
1.1 x 10-1 mg/kg-day |
300 | Medium | |
| Hematologic |
5
x 10-3
(Chronic) |
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats |
BMD
(HED):
5.2 x 10-1 mg/kg-day |
100 | Medium | |
| Developmental |
5
x 10-4
(Subchronic) |
Decreased postnatal (PND 0) body weight in F1 Sprague‑Dawley male and female rats |
BMD
(HED):
4.8 x 10-2 mg/kg-day |
100 | Medium | |
| Hepatic |
1
x 10-3
(Subchronic) |
Increased hepatocellular hypertrophy in adult rats |
BMD
(HED):
1.1 x 10-1 mg/kg-day |
100 | Medium | |
| Hematologic |
8
x 10-4
(Subchronic) |
Decreased red blood cells in adult female Crl:CD Sprague‑Dawley rats |
BMD
(HED):
7.8 x 10-2 mg/kg-day |
100 | Low/Medium | |
| Endocrine |
1
x 10-3
(Subchronic) |
Decreased total T4 in adult male Harlan Sprague-Dawley rats |
BMD
(HED):
2.9 x 10-2 mg/kg-day |
300 | Medium |
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Critical Effect Systems
Chemical Structure for
Perfluorohexanoic Acid (PFHxA)
