Perfluorobutanoic Acid (PFBA)
CASRN 375-22-4 | DTXSID4059916
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(6 pp, 364 K)
Last Updated: 12/22/2022
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Endocrine, Hepatic | 1 x 10 -3
(Chronic) |
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) |
NOAEL
(HED):
1.27
mg/kg-day |
1000 | Medium |
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(6 pp, 364 K)
Last Updated: 12/22/2022
Information reviewed but value not estimated.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (6 pp, 364 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (6 pp, 364 K)
Not assessed under the IRIS Program.
Organ/System-Specific RfDs
| System | RfD (mg/kg-day) | Basis | PoD | UF | Confidence | Notes |
|---|---|---|---|---|---|---|
| Endocrine, Hepatic |
1
x 10-3
(Chronic) |
Increased hepatocellular hypertrophy (Liver), Decreased total T4 (Thyroid) |
NOAEL
(HED):
1.27 mg/kg-day |
1000 | Medium | |
| Hepatic |
1
x 10-3
(Chronic) |
Increased hepatocellular hypertrophy |
NOAEL
(HED):
1.27 mg/kg-day |
1000 | Medium | |
| Developmental |
6
x 10-3
(Chronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium | |
| Developmental |
6
x 10-3
(Subchronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium | |
| Hepatic |
1
x 10-2
(Subchronic) |
Increased hepatocellular hypertrophy |
NOAEL
(HED):
1.27 mg/kg-day |
100 | Medium | |
| Endocrine |
1
x 10-2
(Subchronic) |
Decreased total T4 |
NOAEL
(HED):
1.27 mg/kg-day |
100 | Low/Medium | |
| Developmental |
6
x 10-3
(Subchronic) |
Developmental delays |
BMDL
(HED):
6.2 x 10-1 mg/kg-day |
100 | Low/Medium |
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Critical Effect Systems
Chemical Structure for
Perfluorobutanoic Acid (PFBA)
