Dichloroacetic acid CASRN 79-43-6 | IRIS

IRIS

Dichloroacetic acid

CASRN 79-43-6 | DTXSID2020428

Toxicological Review (PDF) (192 pp, 1.71 M)
IRIS Summary (PDF) (40 pp, 324 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (40 pp, 324 K) Last Updated: 09/11/2003

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Nervous, Reproductive, Hepatic	4 x 10 ^-3	Lesions observed in the testes, cerebrum, cerebellum, and liver.	LOAEL : 12.5 mg/kg-day	3000	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (40 pp, 324 K) Last Updated: 09/11/2003
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (40 pp, 324 K) Last Updated: 09/11/2003

WOE Characterization	Framework for WOE Characterization
Likely to be carcinogenic to humans	Revised Draft Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1999)

Basis:

EPA believes that DCA is likely to be a carcinogen in humans.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (40 pp, 324 K)

Oral Slope Factor: 5 x 10^-2 per mg/kg-day
Drinking Water Unit Risk: 1.4 x 10^-6 per µg/L
Extrapolation Method: Multistage model with Benchmark Dose Modeling
Tumor site(s): Hepatic
Tumor type(s): Hepatoadenoma and Hepatocarcinoma (DeAngelo et. al., 1999)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (40 pp, 324 K)

Information reviewed but value not estimated.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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