Hydrogen Cyanide and Cyanide Salts CASRN Various | IRIS

IRIS

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Reproductive	6 x 10 ^-4	Decreased cauda epididymis weight in male F344/N rats	BMDL (1SD): 1.9 mg/kg-day	3000	Low/Medium

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Endocrine	8 x 10 ^-4	Thyroid enlargement and altered iodide uptake	LOAEL (ADJ): 2.5 mg/m³	3000	Low/Medium

Weight of Evidence for Cancer (PDF) (27 pp, 243 K) Last Updated: 09/28/2010

WOE Characterization	Framework for WOE Characterization
Inadequate information to assess carcinogenic potential	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the U.S. EPA (2005a) Guidelines for Carcinogen Risk Assessment, there is "inadequate information to assess the carcinogenic potential" of cyanide.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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