Ethylene glycol monobutyl ether (EGBE) (2-Butoxyethanol) CASRN 111-76-2 | IRIS

IRIS

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hematologic	1 x 10 ^-1	Hemosiderin deposition in the liver	BMDL (HED): 1.4 mg/kg-day	10	Medium/High

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Hematologic	1.6	Hemosiderin deposition in the liver	BMCL (HEC): 16 mg/m³	10	Medium/High

Weight of Evidence for Cancer (PDF) (31 pp, 297 K) Last Updated: 03/31/2010

WOE Characterization	Framework for WOE Characterization
Not likely to be carcinogenic to humans	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005), EGBE is deemed "not likely to be carcinogenic to humans" at environmental concentrations at or below the RfD and RfC, based on laboratory animal evidence, mode-of-action information, and limited human study information.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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