1,2-Diphenylhydrazine
CASRN 122-66-7 | DTXSID7020710
- IRIS Summary (PDF) (11 pp, 107 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(11 pp, 107 K)
Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(11 pp, 107 K)
Last Updated: 11/01/1991
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(11 pp, 107 K)
Last Updated: 01/31/1987
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Positive results of studies in both rats and mice form the basis for this classification. Two apparently negative studies lack information on compound purity, experimental design, and statistical treatment.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (11 pp, 107 K)
Oral Slope Factor:
8.0
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
2.2
x 10-5
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas and neoplastic liver nodules (NCI, 1979)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (11 pp, 107 K)
Inhalation Unit Risk:
2.2
x 10-4
per µg/m3
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinomas and neoplastic liver nodules (NCI, 1979)
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