Di(2-ethylhexyl)adipate CASRN 103-23-1 | IRIS

IRIS

Di(2-ethylhexyl)adipate

CASRN 103-23-1 | DTXSID0020606

IRIS Summary (PDF) (17 pp, 135 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (17 pp, 135 K) Last Updated: 07/01/1992

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Developmental, Hepatic, Urinary, Musculoskeletal, Other	6 x 10 ^-1	Changes in body weight and liver weight increased liver weight of male and female parents reduced ossification and slightly dilated ureters in fetuses reduced offspring weight gain, total litter weight, and litter size	NOAEL : 1.70 x 10² mg/kg-day	300	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (17 pp, 135 K)
Not assessed under the IRIS Program.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (17 pp, 135 K) Last Updated: 08/01/1991

WOE Characterization	Framework for WOE Characterization
C (Possible human carcinogen)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Based on an absence of human data and increased incidence of liver tumors in female mice. Except for a positive dominant lethal assay, there was no evidence of genotoxicity; this compound does, however, exhibit structural relationships to other nongenotoxic compounds classified as probable and possible human carcinogens.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (17 pp, 135 K)

Oral Slope Factor: 1.2 x 10^-3 per mg/kg-day
Drinking Water Unit Risk: 3.4 x 10^-8 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Combined hepatocellular adenomas and carcinomas (NTP, 1982)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (17 pp, 135 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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