Benzyl chloride
CASRN 100-44-7 | DTXSID0020153
- IRIS Summary (PDF) (13 pp, 118 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(13 pp, 118 K)
Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(13 pp, 118 K)
Last Updated: 01/01/1992
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(13 pp, 118 K)
Last Updated: 08/01/1989
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Based on inadequate human data and sufficient evidence of carcinogenicity in animals; namely significantly increased incidences of benign and malignant tumors at multiple sites in both sexes of mice and a significant increase in thyroid tumors in female rats. There was evidence of mutagenicity in a variety of test systems.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 118 K)
Oral Slope Factor:
1.7
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
4.9
x 10-6
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Endocrine
Tumor type(s): Thyroid, C-cell adenoma/ carcinoma (Lijinsky, 1986)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 118 K)
Not Assessed under the IRIS Program.
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