Prochloraz
CASRN 67747-09-5 | DTXSID4024270
- IRIS Summary (PDF) (13 pp, 114 K)
- Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(13 pp, 114 K)
Last Updated: 01/01/1989
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 9 x 10 -3 | Increase in SAP and liver weights, liver histopathology |
NOEL
:
9.0
x 10-1 mg/kg-day |
100 | High |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(13 pp, 114 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(13 pp, 114 K)
Last Updated: 10/01/1989
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| C (Possible human carcinogen) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Statistically significantly increased incidence and dose-related trend in liver adenomas and carcinomas (combined) in both sexes of one strain of mouse.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (13 pp, 114 K)
Oral Slope Factor:
1.5
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
4.3
x 10-6
per µg/L
Extrapolation Method: Male mice: time-to-tumor linearized multistage procedure in dose, Weibull in time. Female mice: linearized multistage procedure
Tumor site(s): Hepatic
Tumor type(s): Liver adenoma/ carcinoma combined (Nor-Am Chemical Co., 1983)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (13 pp, 114 K)
Not Assessed under the IRIS Program.
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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