Bis(chloromethyl)ether (BCME) CASRN 542-88-1 | IRIS

IRIS

Bis(chloromethyl)ether (BCME)

CASRN 542-88-1 | DTXSID8020173

IRIS Summary (PDF) (12 pp, 113 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (12 pp, 113 K) Last Updated:
Not assessed under the IRIS Program.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (12 pp, 113 K) Last Updated: 07/01/1991
Information reviewed but value not estimated.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (12 pp, 113 K) Last Updated: 09/26/1988

WOE Characterization	Framework for WOE Characterization
A (Human carcinogen)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Statistically significant increases in lung tumors (oat cell carcinomas) observed in six studies of exposed workers and bioassay data from rats and mice.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 113 K)

Oral Slope Factor: 2.2 x 10² per mg/kg-day
Drinking Water Unit Risk: 6.2 x 10^-3 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 113 K)

Inhalation Unit Risk: 6.2 x 10^-2 per µg/m³
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Respiratory
Tumor type(s): Respiratory tract tumors (Kuschner et al., 1975)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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