Aniline
CASRN 62-53-3 | DTXSID8020090
- IRIS Summary (PDF) (19 pp, 139 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(19 pp, 139 K)
Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(19 pp, 139 K)
Last Updated: 11/01/1990
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hematologic | 1 x 10 -3 | Methemoglobin increase, spleen toxicity |
NOAEL
(HEC):
3.4
mg/m3 |
3000 | Low |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(19 pp, 139 K)
Last Updated: 09/07/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Induction of tumors of the spleen and the body cavity in two strains of rat, and some supporting genetic toxicological evidence.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (19 pp, 139 K)
Oral Slope Factor:
5.7
x 10-3
per mg/kg-day
Drinking Water Unit Risk:
1.6
x 10-7
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Immune
Tumor type(s): Spleen, combined fibrosarcoma, stromal sarcoma, capsular sarcoma and hemangiosarcoma (CIIT, 1982)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (19 pp, 139 K)
Not Assessed under the IRIS Program.
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