Cyanide, free
CASRN 57-12-5 | DTXSID6023991
- Toxicological Review (PDF) (153 pp, 905 K)
- IRIS Summary (PDF) (27 pp, 243 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(27 pp, 243 K)
Last Updated: 09/28/2010
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Reproductive | 6.3 x 10 -4 | Decreased cauda epididymis weight in male F344/N rats. The RfD for cyanide, free is presented in section 1.A.3 of the hydrogen cyanide and cyanide salts IRIS Summary. | 3000 | Low/Medium |
Note: The RfD for cyanide, free was calculated using toxicological data for CN-. See ("related topics") for additional details.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(27 pp, 243 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(27 pp, 243 K)
Last Updated: 03/01/1991
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Pertinent data regarding carcinogenicity have not been located in the available literature.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (27 pp, 243 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (27 pp, 243 K)
Not assessed under the IRIS Program.
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