Butyl benzyl phthalate (BBP)
CASRN 85-68-7 | DTXSID3020205
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(12 pp, 111 K)
Last Updated: 09/01/1989
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 2 x 10 -1 | Significantly increased liver-to-body weight and liver-to-brain weight ratios |
NOAEL
:
1.59
x 102 mg/kg-day |
1000 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(12 pp, 111 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(12 pp, 111 K)
Last Updated: 08/22/1988
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| C (Possible human carcinogen) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Based on statistically significant increase in mononuclear cell leukemia in female rats; the response in male rats was inconclusive and there was no such response in mice.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (12 pp, 111 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (12 pp, 111 K)
Not assessed under the IRIS Program.
Program Outlook Details
| Public Assessment Materials | Date |
|---|---|
| Preliminary Assessment Materials/Systematic Review Protocol | Sep-2014 |
| Discontinued | Dec-2018 |
Note: The butyl benzyl phthalate (bbp) (re)assessment has been discontinued. A new/updated assessment will not be added to the IRIS database at this time.
- Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
- Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
- Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.
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