N-Nitrosodiethanolamine
CASRN 1116-54-7 | DTXSID7021027
- IRIS Summary (PDF) (9 pp, 98 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(9 pp, 98 K)
Last Updated:
Not assessed under the IRIS Program.
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(9 pp, 98 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(9 pp, 98 K)
Last Updated: 09/30/1987
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Increased incidence of liver tumors and tumors at other sites in three strains of rats and in hamsters
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (9 pp, 98 K)
Oral Slope Factor:
2.8
per mg/kg-day
Drinking Water Unit Risk:
8.0
x 10-5
per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma, cholangiocellular carcinoma and adenoma and neoplastic nodules (Lijinsky and Kovatch, 1985)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (9 pp, 98 K)
Not Assessed under the IRIS Program.
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