Dichloropropene CASRN 542-75-6 | IRIS

IRIS

1,3-Dichloropropene

CASRN 542-75-6 | DTXSID1022057

Toxicological Review (PDF) (83 pp, 394 K)
IRIS Summary (PDF) (34 pp, 213 K)

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (34 pp, 213 K) Last Updated: 05/25/2000

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Gastrointestinal	3 x 10 ^-2	Chronic irritation	BMDL ₁₀ : 3.4 mg/kg-day	100	High

Reference Concentration for Inhalation Exposure (RfC) (PDF) (34 pp, 213 K) Last Updated: 05/25/2000

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Respiratory	2 x 10 ^-2	Hypertrophy/ hyperplasia of the nasal respiratory epithelium	BMCL ₁₀ (HEC): 7.2 x 10^-1 mg/m³	30	High

Cancer Assessment

Weight of Evidence for Cancer (PDF) (34 pp, 213 K) Last Updated: 05/25/2000

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Known/likely human carcinogen	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Although the available human data are inadequate, 1,3-dichloropropene is characterized as "likely" to be a human carcinogen in accordance with the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996).
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (34 pp, 213 K)

Oral Slope Factor: 1 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 3 x 10^-6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Urinary
Tumor type(s): Urinary bladder carcinoma (NTP, 1985)

Oral Slope Factor: 5 x 10^-2 per mg/kg-day
Drinking Water Unit Risk: 2 x 10^-6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma/carcinoma (NTP, 1985)

Oral Slope Factor: 5 x 10^-2 per mg/kg-day
Drinking Water Unit Risk: 1 x 10^-6 per µg/L
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenoma/carcinoma (Stott et al., 1995)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (34 pp, 213 K)

Inhalation Unit Risk: 4 x 10^-6 per µg/m³
Extrapolation Method: Linearized multistage model, extra risk
Tumor site(s): Respiratory
Tumor type(s): Bronchioalveolar adenoma (Lomax et al., 1989)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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