1,1,1-Trichloroethane
CASRN 71-55-6 | DTXSID0021381
- Toxicological Review (PDF) (237 pp, 1.08 M)
- IRIS Summary (PDF) (55 pp, 386 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(55 pp, 386 K)
Last Updated: 09/28/2007
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Other | 2
(Chronic) |
Reduced body weight |
BMDL
10
:
2155
mg/kg-day |
1000 | Low/Medium |
| Other | 7
(Subchronic) |
Reduced body weight |
BMDL
10
:
2155
mg/kg-day |
300 | Low/Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(55 pp, 386 K)
Last Updated: 09/28/2007
| System | RfC (mg/m3) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 5
(Chronic) |
Liver histopathologic changes |
NOAEL
(HEC):
1553
mg/m3 |
100 | Medium |
| Hepatic | 5
(Subchronic) |
Liver histopathologic changes |
NOAEL
(HEC):
1553
mg/m3 |
100 | Medium |
| Nervous | 5
(Short-term) |
Performance on neurobehavioral tests |
LOAEL
:
526
mg/kg-day |
100 | Medium |
| Nervous | 6
(Acute: 24 hours) |
Performance on neurobehavioral tests |
NOAEL
:
950
mg/m3 |
100 | Medium |
| Nervous | 7
(Acute: 8 hours) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
| Nervous | 7
(Acute: 4 hours) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
| Nervous | 9
(Acute: 1 hour) |
Performance on neurobehavioral tests |
LOAEL
:
950
mg/m3 |
100 | Medium |
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(55 pp, 386 K)
Last Updated: 09/28/2007
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Inadequate information to assess carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), the database for 1,1,1-trichloroethane provides "inadequate information to assess carcinogenic potential."
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (55 pp, 386 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (55 pp, 386 K)
Not assessed under the IRIS Program.
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