1,1,2,2-Tetrachloroethane
CASRN 79-34-5 | DTXSID7021318
- Toxicological Review (PDF) (153 pp, 907 K)
- IRIS Summary (PDF) (29 pp, 250 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(29 pp, 250 K)
Last Updated: 09/30/2010
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Hepatic | 5 x 10 -2
(Subchronic) |
Increased relative liver weight in rats |
BMDL
1SD
:
15
mg/kg-day |
300 | Medium |
| Hepatic | 2 x 10 -2
(Chronic) |
Increased relative liver weight in rats |
BMDL
1SD
:
15
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(29 pp, 250 K)
Last Updated: 09/30/2010
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(29 pp, 250 K)
Last Updated: 09/30/2010
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Likely to be carcinogenic to humans | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a) 1,1,2,2-tetrachloroethane is "likely to be carcinogenic to humans."
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (29 pp, 250 K)
Oral Slope Factor:
2
x 10-1
per mg/kg-day
Drinking Water Unit Risk:
6
x 10-6
per µg/L
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (LED10).
Tumor site(s): Hepatic
Tumor type(s): hepatocellular carcinomas (NCI, 1978)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (29 pp, 250 K)
Information reviewed but value not estimated.
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