Dichlorvos CASRN 62-73-7 | IRIS

IRIS

Dichlorvos

CASRN 62-73-7 | DTXSID5020449

IRIS Summary (PDF) (33 pp, 201 K)
Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (33 pp, 201 K) Last Updated: 11/01/1993

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Nervous	5 x 10 ^-4	Plasma and RBC ChE inhibition in males and females brain ChE inhibition in males	NOAEL : 5 x 10^-2 mg/kg-day	100	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (33 pp, 201 K) Last Updated: 06/01/1994

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous	5 x 10 ^-4	Decreased brain cholinesterase activity	NOAEL (HEC): 5 x 10^-2 mg/m³	100	Medium

Cancer Assessment

Weight of Evidence for Cancer (PDF) (33 pp, 201 K) Last Updated: 10/01/1989

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)

Basis:

Significant increases in forestomach tumors in female and male B6C3F1 mice and leukemias and pancreatic acinar adenomas in Fischer 344 rats. Supporting evidence included observation of tumors at other sites in the rat and observation of mutagenicity for both dichlorvos and a major metabolite dichloroacetaldehyde. A structurally related material, dichloropropene, also induces forestomach tumors in rodents.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (33 pp, 201 K)

Oral Slope Factor: 2.9 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 8.3 x 10^-6 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hematologic, Endocrine, Gastrointestinal
Tumor type(s): Forestomach tumors, pancreatic acinar adenoma, leukemia (NTP, 1986a,b)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (33 pp, 201 K)

Not Assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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