Chlordane (Technical) CASRN 12789-03-6 | IRIS

IRIS

Chlordane (Technical)

CASRN 12789-03-6 | DTXSID5023954

Toxicological Review (PDF) (73 pp, 228 K)
IRIS Summary (PDF) (46 pp, 262 K)
Status: EPA announced in a 2004 Federal Register Notice that chemicals used as pesticides would not be re-assessed by the IRIS Program. This entry in the IRIS database is preserved at the request of EPA program and regional offices. Additional toxicological information may be found under "Other EPA Information."

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (46 pp, 262 K) Last Updated: 02/07/1998

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Hepatic	5 x 10 ^-4	Hepatic necrosis	NOAEL : 1.5 x 10^-1 mg/kg-day	300	Medium

Reference Concentration for Inhalation Exposure (RfC) (PDF) (46 pp, 262 K) Last Updated: 02/07/1998

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Hepatic	7 x 10 ^-4	Hepatic effects	NOAEL (HEC): 6.5 x 10^-1 mg/m³	1000	Low

Cancer Assessment

Weight of Evidence for Cancer (PDF) (46 pp, 262 K) Last Updated: 02/07/1998

WOE Characterization	Framework for WOE Characterization
B2 (Probable human carcinogen - based on sufficient evidence of carcinogenicity in animals)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Known/likely human carcinogen	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Under the 1996 Proposed Guidelines, chlordane would be characterized as a likely carcinogen by all routes of exposure.
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (46 pp, 262 K)

Oral Slope Factor: 3.5 x 10^-1 per mg/kg-day
Drinking Water Unit Risk: 1 x 10^-5 per µg/L
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (IRDC, 1973; NCI, 1977; Khasawinah and Grutsch, 1989b)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (46 pp, 262 K)

Inhalation Unit Risk: 1 x 10^-4 per µg/m³
Extrapolation Method: Linearized multistage procedure, extra risk
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular carcinoma (IRDC, 1973; NCI, 1977; Khasawinah and Grutsch, 1989b)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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