Benzidine
CASRN 92-87-5 | DTXSID2020137
- IRIS Summary (PDF) (16 pp, 129 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(16 pp, 129 K)
Last Updated: 01/01/1989
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous, Hepatic | 3 x 10 -3 | Brain cell vacuolization; liver cell alterations in females |
LOAEL
:
2.7
mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(16 pp, 129 K)
Last Updated: 07/01/1991
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(16 pp, 129 K)
Last Updated: 03/31/1987
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| A (Human carcinogen) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- Observation of increased incidence of bladder cancer and bladder cancer-related deaths in exposed workers
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (16 pp, 129 K)
Oral Slope Factor:
2.3
x 102
per mg/kg-day
Drinking Water Unit Risk:
6.7
x 10-3
per µg/L
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (16 pp, 129 K)
Inhalation Unit Risk:
6.7
x 10-2
per µg/m3
Extrapolation Method: One-hit with time factor, extra risk
Tumor site(s): Urinary
Tumor type(s): Bladder tumors (Zavon, 1973)
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