1,2,4-Trichlorobenzene
CASRN 120-82-1 | DTXSID0021965
- IRIS Summary (PDF) (14 pp, 118 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(14 pp, 118 K)
Last Updated: 05/01/1992
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Endocrine | 1 x 10 -2 | Increased adrenal weights; vacuolization of zona fasciculata in the cortex |
NOAEL
:
1.48
x 101 mg/kg-day |
1000 | Medium |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(14 pp, 118 K)
Not assessed under the IRIS Program.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 118 K)
Last Updated: 06/01/1989
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| D (Not classifiable as to human carcinogenicity) | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986) |
- A dermal exposure study in mice was found inadequate for drawing conclusions as to carcinogenicity in humans.
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 118 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 118 K)
Not assessed under the IRIS Program.
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