Tetrachloroethylene (Perchloroethylene) CASRN 127-18-4 | IRIS

IRIS

Tetrachloroethylene (Perchloroethylene)

CASRN 127-18-4 | DTXSID2021319

Toxicological Review (PDF) (1077 pp, 144.2 M)
IRIS Summary (PDF) (38 pp, 350 K)
Supporting Documents for Tetrachloroethylene

Noncancer Assessment

Reference Dose for Oral Exposure (RfD) (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

System	RfD (mg/kg-day)	Basis	PoD	Composite UF	Confidence
Nervous, Ocular	6 x 10 ^-3	(See Note)			Medium

Note: The RfD was derived as a midpoint of two candidate RfDs from studies that reported neurotoxicity in occupationally-exposed adults: 0.0097 mg/kg-day based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.0026 mg/kg-day based on changes in color vision (Cavalleri et al., 1994). See Section I.A.1 of the IRIS Summary for Tetrachloroethylene for more information.

Reference Concentration for Inhalation Exposure (RfC) (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous, Ocular	4 x 10 ^-2	(See Note)			Medium

Note: The RfC was derived as a midpoint of two candidate RfCs from studies that reported neurotoxicity in occupationally-exposed adults: 0.056 mg/m³ based on changes in reaction time and cognitive effects (Echeverria et al., 1995) and 0.015 mg/m³ based on changes in color vision (Cavalleri et al., 1994). See Section I.B.1 of the IRIS Summary for Tetrachloroethylene for more information.

Cancer Assessment

Weight of Evidence for Cancer (PDF) (38 pp, 350 K) Last Updated: 02/10/2012

WOE Characterization	Framework for WOE Characterization
Likely to be carcinogenic to humans	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005)

Basis:

Following EPA (2005a) Guidelines for Carcinogen Risk Assessment, tetrachloroethylene is "likely to be carcinogenic in humans by all routes of exposure."
This may be a synopsis of the full weight-of-evidence narrative.

Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (38 pp, 350 K)

Oral Slope Factor: 2.1 x 10^-3 per mg/kg-day
Drinking Water Unit Risk: 6.1 x 10^-8 per µg/L
Extrapolation Method: Multistage model (with linear extrapolation from the point of departure (BMDL10), followed by route-to-route extrapolation to the oral route and interspecies extrapolation using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)

Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (38 pp, 350 K)

Inhalation Unit Risk: 2.6 x 10^-7 per µg/m³
Extrapolation Method: Multistage model with linear extrapolation from the point of departure (BMCL10), followed by extrapolation to humans using the PBPK model of Chiu and Ginsberg (2011).
Tumor site(s): Hepatic
Tumor type(s): Hepatocellular adenomas or carcinomas (JISA, 1993)

Sep 2011: IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (Interagency Science Discussion Draft) (Report)

Mar 2011: IRIS Toxicological Review of Tetrachloroethylene (Perchloroethylene) (External Review Draft) (Report)

Jan 2004: Charge to the Tetrachloroethylene (Perchloroethylene) Neurotoxicity Expert Panel (Other)

Sep 2001: IRIS Toxicological Review and Summary Documents For Tetrachloroethylene (Report)

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

You will need Adobe Reader to view some of the files on this page. See EPA's PDF page to learn more.

US EPA

IRIS