2,2',4,4'-Tetrabromodiphenyl ether (BDE-47)
CASRN 5436-43-1 | DTXSID3030056
- Toxicological Review (PDF) (85 pp, 380 K)
- IRIS Summary (PDF) (14 pp, 128 K)
Noncancer Assessment
Reference Dose for Oral Exposure (RfD) (PDF)
(14 pp, 128 K)
Last Updated: 06/30/2008
| System | RfD (mg/kg-day) | Basis | PoD | Composite UF | Confidence |
|---|---|---|---|---|---|
| Nervous | 1 x 10 -4 | Neurobehavioral effects |
BMDL
(1SD):
0.35
mg/kg |
3000 | Low |
Reference Concentration for Inhalation Exposure (RfC) (PDF)
(14 pp, 128 K)
Last Updated: 06/30/2008
Information reviewed but value not estimated.
Cancer Assessment
Weight of Evidence for Cancer (PDF)
(14 pp, 128 K)
Last Updated: 06/30/2008
| WOE Characterization | Framework for WOE Characterization |
|---|---|
| Inadequate information to assess carcinogenic potential | Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005) |
- Under the Guidelines for Carcinogen Risk Assessment (U.S. EPA, 2005a), there is "inadequate information to assess the carcinogenic potential" of 2,2',4,4'-tetrabromodiphenyl ether (BDE-47).
- This may be a synopsis of the full weight-of-evidence narrative.
Quantitative Estimate of Carcinogenic Risk from Oral Exposure (PDF) (14 pp, 128 K)
Not assessed under the IRIS Program.
Quantitative Estimate of Carcinogenic Risk from Inhalation Exposure (PDF) (14 pp, 128 K)
Not assessed under the IRIS Program.
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