Methyl chloride CASRN 74-87-3 | IRIS

IRIS

Reference Dose for Oral Exposure (RfD) (PDF) (23 pp, 165 K) Last Updated: 07/17/2001
Not assessed under the IRIS Program.

System	RfC (mg/m³)	Basis	PoD	Composite UF	Confidence
Nervous	9 x 10 ^-2	Cerebellar lesions	NOAEL (HEC): 9.46 x 10¹ mg/m³	1000	Medium

Weight of Evidence for Cancer (PDF) (23 pp, 165 K) Last Updated: 07/17/2001

WOE Characterization	Framework for WOE Characterization
D (Not classifiable as to human carcinogenicity)	Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1986)
Carcinogenic potential cannot be determined	Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996)

Basis:

Applying the criteria for evaluating the overall weight-of-evidence for carcinogenicity to humans outlined in EPA's guidelines for carcinogen risk assessment (U.S. EPA, 1986), methyl chloride is most appropriately designated a Group D - Not classifiable as to its human carcinogenicity. Using the Proposed Guidelines for Carcinogen Risk Assessment (U.S. EPA, 1996), the available data suggest that methyl chloride would be classified as an agent whose carcinogenic potential cannot be determined.
This may be a synopsis of the full weight-of-evidence narrative.

Not assessed under the IRIS Program.

Not assessed under the IRIS Program.

Additional EPA toxicity information may be available by visiting the following sites:

Human Health Benchmarks for Pesticides (HHBP). This database provides human health benchmarks for pesticides that may be present in drinking water.
Office of Pesticide Programs Pesticide Chemical Search. This database provides links to health effects information and registration status for pesticides.
Chemistry Dashboard. This database provides information on chemical structures, experimental and predicted physicochemical, and toxicity data.

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